동공 산동제와 축동제가 섬유주세포에 미치는 영향

• 영문명: Effects of Pupil Dilation and Constriction Agents on Trabecular Meshwork Cells
• 발행기관: 대한안과학회
• 저자명: 이정훈 김재우,Jeong Hun Lee, MD, Jae Woo Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number9, 1089~1093쪽, 전체 5쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2011.09.15

영문 초록

Purpose: To investigate the effects of pupil dilation and constriction agents on the survival and production of nitric oxide (NO) in cultured human trabecular meshwork cells (HTMC). Methods: Primarily cultured HTMC were exposed to 0, 0.01, and 0.1 mg/ml of tropicamide, cyclopentolate, atropine, or pilocarpine for 2 hours. Cellular survival and production of NO were assessed using the MTT assay and Griess assay, respectively. Results: Tropicamide, cyclopentolate, atropine, and pilocarpine decreased cellular survival at the concentration of 0.1 mg. At the concentration of 0.01 mg/ml, all agents decreased production of NO to some extent, although the reduction was not statistically significant. Conclusions: Pupil dilation and constriction agents may be toxic to HTMC if used at high concentrations or if used frequently in the short-term but may not affect trabecular outflow. J Korean Ophthalmol Soc 2011;52(9):1089-1093

키워드

Atropine, Cyclopentolate, Pilocarpine, Trabecular meshwork cells, Tropicamide