건성안을 동반한 갑상샘안병증에서 0.05% 사이클로스포린 A 점안액 사용 후 눈물막과 안구표면의 변화

• 영문명: Effect of Topical 0.05% Cyclosporine A in Dry Eye Associated With Thyroid Ophthalmopathy
• 발행기관: 대한안과학회
• 저자명: 최원 박영걸 조재갑 윤경철,Won Choi, MD, Yeoung-Geol Park, MD, Jae-Kap Cho, MD, Kyung-Chul Yoon, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number10, 1319~1326쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2010.10.15

영문 초록

Purpose: The present study was performed to evaluate the changes in tear film and ocular surface parameters after using sodium hyaluronate (SH) 0.1% alone or in combination with cyclosporine A (CsA) 0.05% in patients with thyroid- associated ophthalmopathy accompanied by dry eye. Methods: A total of 72 eyes from 36 patients were divided into two groups; 36 eyes of 18 patients were treated with 0.1% SH alone (group 1), and 36 eyes of 18 patients were treated with SH 0.1% and CsA 0.05% (group 2). Tear break-up time (BUT), basal tear secretion test (BST), tear clearance rate (TCR), fluorescein staining (FS) and corneal sensitivity test (CST) were evaluated at pre-treatment and one, three and six months post-treatment. Conjunctival impression cytology was performed and tear CXCL11 (Chemokine (C-X-C motif) ligand) levels were measured pre-treatment and three months post-treatment. Results: BUT, BST, TCR, KEP and CST were significantly improved at six months in group 1 (p < 0.05) and at three months in group 2 (p < 0.05). The degree of conjunctival squamous cell metaplasia, goblet cell density and tear CXCL11 levels were significantly changed at three months in group 2 (p < 0.05). However, there were no significant changes in group 1 after 3 months. Conclusions: Combined use of topical 0.1% SH and 0.05% CsA can result in early improvement in tear films and ocular surface parameters in patients with thyroid-associated ophthalmopathy accompanied by dry eye. J Korean Ophthalmol Soc 2010;51(10):1319-1326

키워드

Cyclosporine, Dry eye syndrome, Sodium hyaluronate, Thyroid associated oph