Valganciclovir를 이용한 거대세포바이러스망막염의 치료

• 영문명: A Case of Valganciclovir Treatment for Cytomegalovirus Retinitis
• 발행기관: 대한안과학회
• 저자명: 김나래 문연성 진희승 윤준호,Na Rae Kim, M.D., Yeon Sung Moon, M.D., Hee Seung Chin, M.D., Jun Ho Yoon, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume49,number3, 531~538쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.03.31

영문 초록

`Purpose: To report a case of a patient with cytomegalovirus (CMV) retinitis who was treated with oral valganciclovir. Case summary: A 34-year-old man who had undergone anti-cancer chemotherapy for Non-Hodgkin lymphoma was referred to the ophthalmologic oncology clinic because of decreased vision in both eyes. Fundus examination showed white, opaque, and granular retinal lesions in both eyes, and a serologic test showed a positive response to CMV antibody IgG and a negative response to CMV antibody IgM. The patient received induction therapy with intravenous ganciclovir and maintenance therapy with oral valganciclovir 900 mg once daily. CMV retinitis reactivated 4 weeks after maintenance therapy was discontinued. At that point, the patient received induction therapy with oral valganciclovir 900 mg twice daily for 3 weeks and maintenance therapy with 900 mg once daily for 5 weeks. The retinal lesion disappeared and did not recur after oral administration of valganciclovir. The patient discontinued valganciclovir after 5 weeks of maintenance therapy, and CMV retinitis did not reactivate during 6 months of follow-up. Conclusion: Oral valganciclovir was clinically effective in the treatment of CMV retinitis in a patient who was treated with anti-cancer chemotherapy for non-Hodgkin lymphoma.`

키워드

Cytomegalovirus Retinitis, Ganciclovir, Valganciclovir