DBA/2J 생쥐에서 점안 안압하강제 투여 후 망막신경세포구성의 변화

• 영문명: Changes in Retinal Neuronal Population in DBA/2J Mice with Topical Intraocular Pressure Lowering Drugs
• 발행기관: 대한안과학회
• 저자명: 박명희 이경민 권재성 문정일,Myoung-Hee Park, M.D., Kyung-Min Lee, M.D., Jae-Sung Kwon, Ph.D., Jung-Il Moon, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume46,number12, 2071~2080쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.12.31

영문 초록

Purpose: The DBA/2J (D2) mouse is a transgenic mouse with pigmentary glaucoma. In a previous study, we found a reduction of inner retinal thickness in D2 mice. We attempted to discover the effect of eye drops on the retina of D2 mice. Methods: Ten-month-old D2 mouse eyes were treated with Timoptic XE?, Cosopt?, and Xalacom? eye drops for a 1-month period. Immunohistochemical staining was performed on the mouse eye sections for analysis. Results: In the control group, GABA and OPN immunoreactivity were markedly decreased and NOS immunoreactivity was increased. In all experimental group, GABA and OPN immunoreactivity were increased, and OPN immunoreactivity was markedly increased especially in the Cosopt?group. NOS immunoreactivity was decreased in all experimental groups. There was no difference in glycine immunoreactivity between the control and experimental groups. Conclusions: Combination anti-glaucoma eye-drops to the D2 mouse changed the retinal neuronal population and these drugs might play an important role in the mechanisms of retinal neuronal death; potential strategies for neuroprotection should therefore be evaluated.

키워드

Amacrine cell, Anti-glaucoma drug, DBA/2J mice, Ganglion cell, Nitrergic cell