갑상선 질환(종양)에서 Cyclooxygenase-2의 발현에 대한 연구

• 영문명: Increased Expression of Cyclooxygenase-2 Protein in Human Thyroid Tumor
• 발행기관: 대한내분비외과학회
• 저자명: 이국종 박희붕 김지훈 정용식 주희재¹ 소의영 Kug Jong Lee M.D. Hee Boong Park M.D. Ji Hoon Kim M.D. Yong Sik Jeong M.D. Hee Jae Joo M.D.¹ and Euy Young Soh M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』2권2호, 90~96쪽, 전체 7쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2002.12.30

영문 초록

Purpose: Thyroid tumor is one of the most common endocrine tumors, and yet little is known about its molecular process of development and progression. Cyclooxygenase (COX)- 2, the inducible form of the COX enzyme for prostaglandin synthesis, is up-regulated in gastrointestinal cancers and is a key mediator of epithelial cell growth. Regular intake of aspirin or other nonsteroidal antiinflammatory drugs (NSAIDs) is associated with a decreased incidence of colorectal, esophageal, gastric, and lung cancer. We sought to determine the involvement of COX-2 in human thyroid cancer. Methods: COX-2 protein was assayed in thyroid tissue of 64 which were inflammatory disease and benign tumor and malignant tumor with or without metastasis patients by using immunohistochemistry and Western Blot analysis. Results: COX-2 protein was not expressed in normal thyroid tissue. But COX-2 protein was expressed strongly in inflammatory tissue. Expression of COX-2 was very high in both benign and malignant tumor. There is no difference in pathology and malignant potential or existence of metastasis. Conclusion: There was no correlation between clinicopathological characteristics of thyroid tumor and intensity of COX-2 protein expression. In addition, there was no difference of expression of COX-2 between inflammatory thyroid disease and thyroid tumor. This study indicates that COX-2 protein over expression may contribute to an early event of gastric cancer development, and it further suggests that selective inhibition of COX-2 may provide a chemopreventive effect against thyroid cancer. (Korean J Endocrine Surg 2002;2:90-96)

키워드

갑상선 종양, Cyclooxygenase (COX)-1, COX-2,Thyroid tumor, Cyclooxygenase (COX)-1, COX-2