갑상선 유두암과 신체질량지수 간의 임상병리학적 관련성

• 영문명: Clinicopathological Relevance between Body Mass Index and Papillary Thyroid Carcinoma
• 발행기관: 대한내분비외과학회
• 저자명: 나안수 강상율 김선광 윤현조 정성후 Ahn Soo Na Sang Yull Kang Seon Kwang Kim Hyun Jo Youn Sung Hoo Jung
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』14권4호, 171~176쪽, 전체 6쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2014.12.30

영문 초록

Purpose: Obesity is a known risk factor for several cancers, including breast, colon, esophagus, kidney, uterus, and thyroid. Recent studies have reported that higher body mass index (BMI) is also associated with more advanced stage. The aim of this study was to investigate the clinicopathological relevance between BMI and papillary thyroid carcinoma (PTC). Methods: A total of 798 patients surgically treated for PTC from January 2006 to June 2010 were included in this study. Medical records and pathologic reports were reviewed retrospectively. According to BMI, patients were divided into four groups: underweight (3.1%), normal (57.3%), overweight (31.6%), and obese (8.0%). Clinicopathological factors were analyzed and compared between normal and other groups. Results: According to the results, 709 patients were women (89.0%) and mean age was 48.5 years; mean follow-up period was 1,721±464.2 days. In comparison between the normal and underweight groups, there was significantly more extra-thyroidal invasion [Odds ratio (OR) 3.923, P=0.006] in the underweight group. In the obese group, tumor size was significantly larger (OR 1.794, P=0.007). However, there was no significant difference between the normal and overweight group. Conclusion: In the obese group, tumor size was the only clinical significant factor between high BMI and PTC. Interestingly, more extra-thyroidal invasion was seen in the underweight group. To confirm this result, further studies with long-term follow-up and more patients are required.

키워드

비만, 신체질량지수, 갑상선 유두암,Obesity, Body mass index, Papillary thyroid carcinoma