갑상선암 환자에서 측경부 림프절 전이여부 진단에 세침흡인세포검사가 믿을만한가?

• 영문명: In Thyroid Cancer Patients, Is Preoperative FNAB-C Reliable for Prediction of Lateral Cervical LN Metastasis?
• 발행기관: 대한내분비외과학회
• 저자명: 서수한1 이정훈2 소의영2 Su Han Seo1 Jung Hun Lee2 Euy Young Soh2
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』14권2호, 76~80쪽, 전체 5쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2014.06.30

영문 초록

Purpose: The goal of this study was to evaluate the diagnostic accuracy of preoperative fine needle aspiration biopsy cytology (FNAB-C) in predicting lateral lymph node metastasis in papillary thyroid cancer patients.Methods: A total of 592 patients who underwent thyroid cancer surgery and intra- operative lateral cervical LN frozen section or RND, from January 2002 to December 2011, were evaluated retrospectively. Among them, 228 cases had suspicious findings in FNAB-C of lateral nodes. We reviewed their radiological and pathological reports.Results: Intra-operative frozen section examination was performed in 540 cases and RND was performed in 314 cases. This study included 534 women (83.4%) and 106 men (16.6%). Patients’ ranged in age from 9 to 83 years (mean, 45.65 years). FNAB-C was per-formed in 228 cases. The sensitivity and specificity of FNAB-C was 71.5% and 78.6%, respectively; 35.9% of cases had a false negative result. The combination of FNAB-C and intra-operative frozen section test sensitivity and specificity was 87.2% and 93.6%, respectively.Conclusion: The results for sensitivity in FNAB-C actually appear low, and false negative results were very high. In papillary thyroid cancer in patients with FNAB-C, even if the result is negative, if lymph node metastasis is suspected based on radiologic evidence, frozen section examination should be performed for determination of metastasis.

키워드

갑상선 암, 측경부 림프절, 세침흡인세포검사, 동결절편조직검사,Thyroid carcinoma, Lateral cervical lymph node, FNAB-C, Frozen section biopsy