Overall Incidence of Posttransplant Malignancies and Clinico-pathologic Features of Thyroid Cancer in Renal Allograft Recipients; 40-years Single Center's Experience

• 영문명: Overall Incidence of Posttransplant Malignancies and Clinico-pathologic Features of Thyroid Cancer in Renal Allograft Recipients; 40-years Single Center's Experience
• 발행기관: 대한내분비외과학회
• 저자명: Hyun Kyu Kim Nam Seop Lee Sohee Lee Ji Il Kim Byung Joo Song In Sung Moon Sang Seol Jung Ja Seong Bae
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』14권1호, 12~17쪽, 전체 6쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2014.03.30

영문 초록

Purpose: Prolonged immunosuppression after kidney transplantation (KT) is known to increase the risk of various cancers; however, few studies on posttransplant thyroid carcinoma (TC) have been reported in the literature. We investigated the incidence of posttransplant malignancies (PTMs) and the clinicopathological features of postransplant TC. Methods: We conducted a retrospective study of 1,622 patients who underwent KT from Mar. 1969 to Dec. 2008. Overall incidence and the standardized incidence ratio (SIR) of posttransplant TC according to the 2007 annual report of the Korea Cancer Center Registry were calculated.Results: During the mean follow-up period of 109 months, 137 (8.4%) recipients were identified as having PTM, including five males and seven females with papillary TC. (0.74%) SIR of the TC was 12.4 in males and 0.5 in females. During the mean follow-up period of 69.1 months, three (25.0%) patients with TC developed loco-regional recurrence.Conclusion: Overall incidence of TC was higher compared to the general Korean population (0.74% vs 0.04%) without differences in gender distribution (P=0.086) and higher tendency of locoregional recurrence in clinical carcinoma (P=0.0512). Therefore, to ensure early detection and favorable outcome of posttransplant TC, frequent surveillance using ultrasonography and prophylactic central neck dissection should be considered.