원발성 알도스테론증으로 부신 절제술 받은 환자의 수술 후 결과에 대한 분석

• 영문명: Postoperative Outcomes in Patients Undergoing Adrenalectomy for Primary Aldosteronism
• 발행기관: 대한내분비외과학회
• 저자명: 류재민 정승필 이정희 김지영 최민영 이세경 길원호 최준호 이정언 김지수 남석진 양정현¹ 김정한 Jai-Min Ryu M.D. Seung-Pil Jung M.D. Jeong-Hee Lee M.D. Ji-Yeong Kim M.D. Min-Yeong Choi M.D. Se-Kyung Lee M.D. Won-Ho Kil M.D. Jun-Ho Choe M.D. Jeong-Eon Lee M.D. Jee Soo Kim M.D. Seok- Jin Nam M.D. Jung-Hyun Yang M.D.¹ and Jung-Han Kim M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』11권4호, 276~282쪽, 전체 7쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2011.12.30

영문 초록

Purpose: Primary aldosteronism (PA) is characterized by hypertension (HTN), hypokalemia, suppressed plasma renin activity, and inappropriate aldosterone secretion. The purpose of this study was to analyze postoperative results on blood pressure (BP), and to determine the factors associated with resolution of HTN after adrenalectomy for PA. Methods: One hundred eight patients (66 females and 42 males) with a mean age of 46 years underwent adrenalectomy for PA between January 1, 1996 and September 30, 2009. Their clinical characteristics and biochemical parameters were reviewed retrospectively. Results: All patients had HTN preoperatively and 20 patients (18.1%) had uncontrolled HTN. Hypokalemia was evident in 89.1% of patients, cardiovascular events in 4.5% and cerebrovascular events in 8.2%. There was a significant decrease in both systolic BP and diastolic BP postoperatively, as compared with that before operation. Median systolic BP decreased from 150 mmHg to 125 mmHg at the last follow-up (P＜0.01), and median diastolic BP decreased from 93.5 mmHg to 81.5 mmHg (P＜0.01). Sixty two (57.4%) patients were cured of HTN and did not require any hypertensive agent, and 38 (35.1%) patients had an improvement in BP control, whereas 9 (8.3%) patients had no change in BP. Univariate analysis showed that duration of HTN and more than two HTN treatment agents were independent factors predicting sustained hypertension after surgery. Conclusion: The duration of HTN and the severity of HTN are factors influencing persistence of HTN after operation for a PA. (Korean J Endocrine Surg 2011;11:276-282)

키워드

부신절제술, 부신 피질선종, 고혈압, 고알도스테론증,Adrenalectomy, Adrenocortical adenoma, Hypertension, Hyperaldosteronism