인간 기도 상피세포에서 증가된 뮤신 생성에 대한 쿠마린과 인도메타신의 억제작용

• 영문명: Suppression of Induced Mucin Production from Human Airway Epithelial Cells by Coumarin and Indomethacin
• 발행기관: 대한약학회
• 저자명: 이재우(Jae Woo Lee) 김길동(Kil-Dong Kim) 전병규(Byeong Kyou Jeon) 이충재(Choong Jae Lee)
• 간행물 정보: 『약학회지』제54권 제5호 (2010년), 416~421쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.10.31

영문 초록

We examined whether indomethacin, noscapine, coumarin, uridine and betaine affect airway mucin production induced by EGF or TNF-α from NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with EGF or TNF-α for 24 h. Of the five compounds, coumarin suppressed airway mucin production induced by EGF or TNF-α. However, indomethacin suppressed airway mucin production induced by EGF. This result suggests that coumarin and indomethacin can regulate the production of mucin induced by EGF, by directly acting on airway epithelial cells.

키워드

airway mucin coumarin indomethacin