조골세포내 PDE4에 의한 PTH 신호의 음성적 조절

• 영문명: The Negative Role of PDE4 on PTH-induced Signaling in Osteoblasts
• 발행기관: 대한약학회
• 저자명: 박효정(Hyojung Park) 노아롱새미(A Long Saemi Noh) 이정민(Jung-Min Lee) 임미정(Mijung Yim)
• 간행물 정보: 『약학회지』제54권 제5호 (2010년), 410~415쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.10.31

영문 초록

We explored the role of phosphodiesterase 4 (PDE4) on parathyroid (PTH)-induced signaling in osteoblasts. PTH was shown to increase the activity of PDE, mainly PDE4, in osteoblasts, which is partly attributable to elevated PDE4B and PDE4D mRNA expression. The use of PDE4 inhibitor strengthened the PTH-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation. Furthermore, the PDE4 inhibitor stimulated PTH-induced receptor activator of nuclear factor-κB ligand (RANKL) expression in osteoblasts, which in turn increased osteoclast formation. Taken together, these data suggest the negative role of PDE4 on PTH-induced signaling in osteoblasts.

키워드

PTH PDE4 osteoblast osteoclast