Quercetin에 의한 혈관이완효과에 대한 알코올의 추가적인 역할

• 영문명: The Synergistic Effect of Additional Ethanol Exposure on Quercetin-induced Vasorelaxation in a Vasoconstrictor-dependent Manner
• 발행기관: 대한약학회
• 저자명: 진영배(Youngbae Jin) 제현동(Hyun Dong Je)
• 간행물 정보: 『약학회지』제54권 제5호 (2010년), 392~397쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.10.31

영문 초록

The aim of present study was to investigate the possible influence and related mechanism of additional alcohol on the flavonoid- induced arterial relaxation. Agonist-induced vascular smooth muscle contractions involve the activation of thick or thin filament pathway. However, there are no reports addressing the question whether this pathway is involved in quercetin-induced relaxation cotreated with alcohol in rat aortae contracted with phorbol ester, fluoride or thromboxane A2 mimetic U-46619. We hypothesized that cotreated alcohol plays a role in vascular relaxation evoked by quercetin in rat aortae. Endothelium-denuded arterial rings from male Sprague-Dawley rats were used and isometric contractions were recorded using a computerized data acquisition system. Quercetin inhibited phorbol ester, fluoride or thromboxane A2-induced contraction regardless of endothelial function. However, alcohol didn't decrease any agonist-induced contraction. Interestingly, only in thromboxane A2-induced contraction, synergistic results were observed in aortae denuded and cotreated with quercetin and alcohol suggesting that additional pathways different from antioxidation or endothelial nitric oxide synthesis might be involved in the vasorelaxation. In conclusion, in the agonists-contracted rat aortae, quercetin and alcohol together showed synergistic response regardless of endothelial function in an agonist-dependent manner.

키워드

alcohol fluoride phorbol ester quercetin Rho-kinase thromboxane A2 mimetic vasoconstriction