히스티딘 중합체가 일차배양 기도 상피세포에서의 뮤신 유리에 미치는 영향

• 영문명: Effects of Histidine Polymers on Mucin Release from Primary Cultured Airway Epithelial Cells
• 발행기관: 대한약학회
• 저자명: 전병규(Byeong Kyou Jeon) 윤인대(In Dae Yun) 이재우(Jae Woo Lee) 이충재(Choong Jae Lee)
• 간행물 정보: 『약학회지』제54권 제5호 (2010년), 334~340쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.10.31

영문 초록

We investigated whether poly-L-histidine (PLH) significantly affect mucin release from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24 hr and chased for 30 min in the presence of PLH to assess the effect on 3H-mucin release. PLH 9,850 and PLH 6,700 specifically inhibit mucin release from airway goblet cells without significant cytotoxicity. This finding suggests that poly-L-histidine might function as an airway mucoregulative agent.

키워드

airway mucin HTSE cells poly-L-histidine