섬오가피 추출물의 항암관련 사이토카인 분비활성

• 영문명: Effects of Acanthopanax koreanum Extracts on Anticancer Related Cytokine Secretions
• 발행기관: 대한약학회
• 저자명: 유수연(Su-Yun Lyu) 박원봉(Won-Bong Park)
• 간행물 정보: 『약학회지』제54권 제4호 (2010년), 232~239쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.08.31

영문 초록

Stems and roots of Acanthopanax koreanum Nakai were extracted with water and treated on immune cells in order to determine their immunomodulatory activites. Various Th-1 type cytokines were measured using ELISA including interleukin (IL)-2, IL-12, interferon-gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α) secreted by dendritic cells, Tcells, intestinal epithelial cells, natural killer cells, and macrophages. As a result, there was a significant increase in IL-12 and IFN-γ, secretion, but there was no change in the secretion of TNF-α. Additionally T-cells slightly increased the secretion of IL-2, but there was a significant increase of IL-2 in intestinal epithelial cells. Therefore, our results suggest that A. koreanum Nakai may act as an immunomodulator by stimulating the cell-mediated immunity which can help the immune system defend against infections or cancer cells.

키워드

Acanthopanax koreanum Cytokines IL-2 IL-12 IFN-γ