정공피으로부터 항염증물질의 연구

• 영문명: Studies on the Antiinflammatory Compounds from Sorbus Commixta
• 발행기관: 대한약학회
• 저자명: 윤용갑(Young Gab Yun) 채규윤(Kyu Yun Chai) 록란잔밭(Kyung Kwan Lee) 이경관(Lok Ranjan Bhatt) 백승화(Seung Hwa Baek)
• 간행물 정보: 『약학회지』제53권 제6호 (2009년), 351~356쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.12.31

영문 초록

Sakuranetin, prunetin and dihydroquercetin were isolated from the methanol extract of Sorbus commixta by 1D/2D-NMR and LC-MASS spectrometry. Medicating these compounds to RAW264.7 cell that was pre-treated by lipopolysaccharide revealed anti-inflammatory effects that greatly inhibited the production of NO (nitric oxide) and PEG2 (prostaglandin E2), which are well known to cause the expression of iNOS (inducible nitric oxide synthase) and COX-2 (Cyclooxygenase-2). These results suggest that these compounds can be used as stable anti-inflammatory materials.

키워드

Sorbus commixta sakuranetin prunetin dihydroquercetin anti-inflammatory effects NO PEG2