녹차추출물과 테아닌 복합물의 신경전달물질 조절을 통한 항스트레스 효과

• 영문명: Combination of Green Tea Extract and L-Theanine Alleviates Electric Foot Shock Induced Stress by Modulating Neurotransmitters in Mice
• 발행기관: 대한약학회
• 저자명: 박상기(Sang-Ki Park) 박형국(Hyoung Kook Park) 김태일(Tae Il Kim) 홍진태(Jin Tae Hong) 이원경(Won Kyung Lee)
• 간행물 정보: 『약학회지』제53권 제5호 (2009년), 241~249쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.10.31

영문 초록

Various neurotransmitters are involved in regulating stress systems. In this study, we investigated the combination relieving effect of green tea extract(GTE) and L-theanine on the stress induced by electric foot shock. Four week oral administration of GTE (24 mg/kg), L-theanine (4 mg/kg) or their combination reduced the levels of dopamine, noradrenaline and corticosterone in blood, brain cortex, hippocampus, and striatum, wherease increased serotonin level. The combination of GTE and L-theanine showed much greater effects than single treatment of each component, and the effects are comparable to diazepam (2 mg/kg). Therefore, this study suggests that the combination of GTE and L-theanine may act effective and be useful for stress relieving treatment.

키워드

green tea extract L-theanine anti-stress neurotransmitter