랫드 일차 배양 간세포에서 에탄올의 독성에 대한 헛개나무 물추출물의 보호효과

• 영문명: Protective Effects of the Water Extracts of Hovenia dulcis Thunb Against Ethanol-Induced Toxicity in Primary Cultured Rat Hepatoc
• 발행기관: 대한약학회
• 저자명: 김종호(Jong Ho Kim) 서영민(Young Min Seo) 김주현(Ju Hyun Kim) 현선희(Sun Hee Hyun) 이상규(Sang Kyu Lee) 김춘화(Chun Hwa Kim) 강미정(Mi Jeong Kang) 전태원(Tae Won Jeon) 윤수홍(Soo Hong Yoon)정태천(Tae Cheon Jeong)
• 간행물 정보: 『약학회지』제52권 제1호 (2008년), 56~61쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.02.28

영문 초록

The hepatoprotective effects of the water extracts of Hovenia dulcis Thunb (HD) were investigated in vitro. Following the induction of hepatotoxicity by ethanol in primary cultures of rat hepatocytes, the protective effects of four different water extracts of HD were determined through serial dose-response and time-dependent studies. The individual extracts used in these studies were prepared from fruits, seeds, leaves and tubes. Treatment of hepatocyte cultures with the water extracts of HD provided a significant protection from the increased lactate dehydrogenase activity induced by ethanol. Particularly, the fruits extract was the most effective against ethanol-induced hepatotoxicity in the primary cultures of rat hepatocytes. The results demonstrated that the extracts might have the protective effect against ethanol-induced toxicity in hepatocyte cultures.

키워드

hepatoprotection Hovenia dulcis Thunb ethanol primary cultures rat hepatocytes lactate dehydrogenase (LDH) leakage