LPS의 파골세포 분화 유도에 미치는 PDE4 저해제의 증강효과

• 영문명: The Effect of PDE4 Inhibitor on LPS-induced Osteoclastogenesis
• 발행기관: 대한약학회
• 저자명: 노아롱새미(A Long Sae Mi No) 천링(Ling Chen) 임미정(Mi jung Yin)
• 간행물 정보: 『약학회지』제52권 제1호 (2008년), 43~47쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.02.28

영문 초록

To determine the regulatory roles of PDE4 inhibitor on LPS-induced osteoclastogenesis, we investigated the effect of a PDE4 inhibitor on osteoclast formation in the presence of LPS. A specific PDE4 inhibitor, rolipram, increased LPS-induced osteoclast formation in cocultures. To verify that whether rolipram acts indirectly on osteoblasts, we investigated the TRANCE and COX-2 mRNA expression levels in osteoblasts. Treatment of rolipram increased the expression of TRANCE and COX-2 mRNA in osteoblasts stimulated by LPS. On the contrary, rolipram did not augment the number of osteoclasts differentiated from bone marrow cells by LPS. In conclusion, the stimulation of LPS-induced osteoclast formation by the PDE4 inhibitor are attributable to its indirect effect on osteoblasts, not to their direct effect on bone marrowderived osteoclast precursors.

키워드

LPS phosphodiesterase 4 inhibitor osteoblast osteoclast