사람 말초혈액 단핵세포에서 흰털오가피 열매 추출물에 의한 Th1/Th2 Cytokine 분비조절

• 영문명: Modulation of Thl/Th2 Cytokine Secretion in Human Peripheral Blood Mononuclear Cells by Water Extract of Acanthopanax divaricatus var. albeofructus Fruits
• 발행기관: 대한약학회
• 저자명: 유수연(Suyun Lyu) 노빛나(Binna Noh) 박원봉(Won Bong Park)
• 간행물 정보: 『약학회지』제52권 제1호 (2008년), 27~32쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.02.28

영문 초록

Water extracts of Acanthopanax divaricatus var. albeofructus (ADA) fruits were used to treat hPBMC to determine the mechanisms for the immunomodulatory effects. The secretion level of various cytokines including Th-1 type (IL- 2, L-12, IFN-γ and TNF-α) and Th-2 type (IL-6, IL-8 and IL-10) were measured using ELISA. A significant increase of Th- 1 type cytokine secretion was observed in the presence of extract while Th-2 cytokine, IL-6 was suppressed. Our results suggest that ADA fruit extract may influence the anticancer immune responses towards a predominance of Th-1 cytokines in the immune system.

키워드

acanthopanax fruits immunomodulatory cytokine Th-1/Th-2 ELISA