사람 카다베르 피부를 통한 케토롤락 트로메타민의 경피 흡수에 L-menthol이 미치는 영향

• 영문명: Effect of L-Menthol on the Percutaneous Absorption of Ketorolac Tromethamine Across Human Cadaver Skin
• 발행기관: 대한약학회
• 저자명: 이용석(Yong Seok Lee) 오흥설(Heung Seol Oh) 김하형(Ha Hyung Kim) 이광표(Kwang Pyo Lee)
• 간행물 정보: 『약학회지』제44권 제6호 (2000년), 595~600쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.12.30

영문 초록

Transdermal delivery of ketorolac tromethamine, a potent non-narcotic analgesic, through human cadaver skin was investigated in vitro. A mixture of ethanol/water (40/60) containing 0, 1, 3, 5, and 8 (w/v)% L-menthol were used as a vehicle and penetration enhancer, respectively. The permeation of ketorolac through human cadaver skin from saturated drug solution was evaluated at 37oC with modified Franz diffusion cell. The in vitro skin flux and lag time were 1.23+/-0.11mcg/cm2.hr and 5.56+/-0.34hr, respectively. The cumulative amount of penetrated ketorolac containing L-menthol in ethanol/water (40/60) binary system was increased by the following order; 3%, 5%, 8%, 1%, 0%, and the lag time was decresed by the following order; 3%, 5%, 8%, 0%, 1%. The results suggested that a potential use of 3% L-menthol is an effective penetration enhancer of ketorolac tromethamine through the human cadaver skin.

키워드

Ketorolac tromethamine enhancer L-menthol skin permeation rate cadaver skin.