Zea mays 불검화추출물을 함유하는 정제의 제제설계 및 평가

• 영문명: Formulation and Evaluation of Tablets Containing Unsaponifiable Fraction of Zea mays
• 발행기관: 대한약학회
• 저자명: 한용해(Yong Hae Han) 정연복(Youn Bok Chung) 한건(Kun Han) 정석재(Suk Jae Chung) 박만기(Man Ki Park) 심창구(Chang Koo Shim)
• 간행물 정보: 『약학회지』제44권 제6호 (2000년), 578~587쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.12.30

영문 초록

The purpose of the present study was to design and prepare the optimum formulation for the oral administration of titrated extract of the unsaponifiable fraction of Zea mays L (ETIZM). For this purpose, we simulated the blood concentration of ETIZM after its oral administration, changing the dissolution rate constants (0.05~20hr-1). In vivo parameters, such as absorption rate constant (ka), elimination rate constant (k) and volume of distribution (Vd), were incorporated in the simulation on the basis of the experiments and literatures. When the dissolution rate constant (kr) is over 5 hr-1, the absorption process appears to be the rate limiting step for the transport of ETIZM from the G.I. ract to the blood circulation. While less than 5 hr-1, the dissolution rate considered to be the rate limiting step. Moreover, the optimum blood concentration was shown in the range from 1 to 5 hr-1 of kr in the simulation. To design and prepare the tablets on the basis of the above results, 7 formula containing HPMC, PEG 4000 and PEG 6000 (1-5%, respectively) were prepared and evaluated. The tablets containing PEG 4000 (1%), PEG 6000 (1%) or PEG 4000 (5%) satisfy the optimum kr range (1-5 hr-1). These formulations, therefore, will be able to show the more effective blood concentration, compared with the commercial products after the oral administration.

키워드

Unsaponifiable fraction of Zea mays L formulation simulation blood concentration dissolution rate.