글리시르히진이 L1210 세포를 이식한 생쥐의 Lymphocytes Subpopulation 변화에 미치는 영향

• 영문명: Effect of Glycyrrhizin on Lymphocytes Subpopulation Change of L1210 cells-transplanted Mice
• 발행기관: 대한약학회
• 저자명: 은재순(Jae Soon Eun) 염정열(Jung Yul Yum) 전훈(Hoon Jeon) 오찬호(Chan Ho Oh)
• 간행물 정보: 『약학회지』제44권 제6호 (2000년), 566~571쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.12.30

영문 초록

We have previously observed that glycyrrhizin(GL) inhibits the proliferation of transplanted-L1210 cells via the production of nitric oxide from peritoneal macrophages. In the present study, we examined the effect of GL on lymphocytes subpopulation change of L1210 cells-transplanted mice. GL increased the population of CD4-CD8+ cells of thymocytes in L1210 cells-transplanted mice and the lucigenin chemiluminescence of human polymorphonuclear cells. These results suggest that the proliferation of transplanted-L1210 cells is partly inhibited by an enhancement of cytotoxic T cells population and phagocytic activity in GL-administered mice.

키워드

Glycyrrhizin B20+ Thy1+ CD4+ CD8+ L1210 phagocytosis.