육미지황탕이 카드뮴 중독된 흰쥐의 간장 약물대사 기능에 미치는 영향

• 영문명: Effects of Yukmijihwang-Tang on the Hepatic Microsomal Function of Cd-poisoned Rat
• 발행기관: 대한약학회
• 저자명: 서은실(Eun Sil Suh) 임종필(Jong Pil Lim)
• 간행물 정보: 『약학회지』제44권 제6호 (2000년), 552~557쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.12.30

영문 초록

In order to investigate the effects of Yukmijihwang-Tang on the hepatic microsomal function of Cd-poisoned rats, 3mg/kg of cadmium (Cd) and 500mg/kg of Yukmijihwang-Tang extract (YJT), a herbal hepatoprotective medicine, were administered concurrently to rats for 4 weeks. The levels of protein, aniline hydroxylase (AH) and malondialdehyde (MDA) were increased in Cd-treated group. This increase was suppressed by treatment of YJT. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose-6-phosphatase (G-6-P) and delta-aminolevulinic acid dehydratase (ALAD) of Cd-treated group were decreased. This decrease was inhibited by treatment of YJT. Treatment with YJT significantly protects cadmium-induced hepatotoxicity.

키워드

Yukmijihwang-Tang Cd-poisoned liver toxicity.