난용성 항진균제 이트라코나졸의 액상제제화에 의한 생체이용율 개선

• 영문명: Enhanced Bioavailability of Itraconazole in Liquid Preparation
• 발행기관: 대한약학회
• 저자명: 황우신(Woo Sin Hwang) 권광일(Kwang Il Kwon) 방규호(Kyu Ho Bang)
• 간행물 정보: 『약학회지』제44권 제6호 (2000년), 528~533쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.12.30

영문 초록

This study was to develop an effective itraconazole liquid preparation which exhibits an enhanced bioavailability. The solubility of itraconazole was increased (72-fold) in itraconazole liquid preparation as compared with itraconazole powder. The dissolution rate of itraconazole was higher for itraconazole liquid preparation filled into a hard gelatin capsule with 90% release within 20 min as compared to 55% for Sporanox(R) capsules. The oral absorption of itraconazole liquid preparation and Sporanox(R) tablets were studied in the rat. The area under the concentration-time curve (AUC0-24hr) of itraconazole liquid preparation (90.25+/-8.36mcg.hr/ml) increased by 6.2 times compared to that of Sporanox(R) tablets (14.58+/-1.26mcg.hr/ml) after oral administration of itraconazole 15mg/rat each. Cmax also increased to 6.87+/-1.15mcg/ml after administration of liquid preparation from 1.58+/-0.16mcg/ml of Sporanox(R) tablets. These results indicate that in vivo bioavailability of itraconazole liquid preparation was significantly enhanced as compared with Sporanox(R) tablets.

키워드

Itraconazole itraconazole liquid preparation bioavailability.