9,10-디플루오르-5,6,6a,7,11b-펜타하이드로인다노[2,1-c]이소퀴놀린의 합성

• 영문명: Synthesis of 9,10-difluoro-5,6,6a,7,11b-pentahydroindano [2,1-c]isoquinoline
• 발행기관: 대한약학회
• 저자명: 마은숙(Eun Sook Ma) 김민정(Min Jung Kim)
• 간행물 정보: 『약학회지』제44권 제6호 (2000년), 505~510쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.12.30

영문 초록

The synthesis of pentahydroindanoisoquinoline (4) compound has been achieved via the cyclization of 2-(N-benzylamino)-5,6-difluoro-1-indanol (10a, 10b), which was prepared by condensation and reduction of 2-amino-1-indanol and benzaldehyde in ethanol. The stereochemistry of H6a and H11b of 9,10-difluoro-5,6,6a,7,11b-pentahydroindano[2,1-c]isoquinoline (4) was the trans B/C ring fusion.

키워드

Indanoisoquinoline trans B/C ring fusion.