Daidzein과 Genistein이 생쥐의 면역 기능에 미치는 영향

• 영문명: Effect of Daidzein and Genistein on Immune Function in Mice
• 발행기관: 대한약학회
• 저자명: 은재순(Jae Soon Eun) 조선경(Sun Kyung Cho) 권진(Jin Kwon) 서은실(Eun Sil Suh) 전훈(Hoon Jeon) 염정열(Jung Yul Yum)
• 간행물 정보: 『약학회지』제44권 제2호 (2000년), 182~188쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.04.29

영문 초록

High soy consumption leading to high exposures of soy isoflavones has been associated with a reduced risk of cancers at many sites. As part of a study focusing on the chemopreventive mechanisms, we have investigated the modulating effects of daidzein and genistein, a prominent and more bioavailable isoflavone in soy foods, on murine immune function. Daidzein (50mg/kg) or genistein (50mg/kg) was administered p. o. once a day for 7 days in BALB/c mice. Daidzein decreased the mitogen-stimulated proliferation of murine splenocyte, but genistein increased it. Daidzein stimulated the secretion of interleukin-4, but inhibited the secretion of gamma-interferon, interleukin-2 and tumor necrosis factor-alpha. Genistein stimulated the secretion of gamma-interferon, interleukin-2 and tumor necrosis factor-alpha, but inhibited the secretion of interleukin-4. Daidzein and genistein inhibited the production of nitric oxide and enhanced the phagocytic activity in peritoneal macrophage. These results suggest that cancer preventive effects of daidzein is partly concerned with the secretion of TH2 cells cytokine and the activation of macrophage phagocytosis, and genistein is partly concerned with the secretion of TH1 cells cytokine, tumor necrosis factor-alpha and the activation of macrophage phagocytosis.

키워드

daidzein genistein cytokine splenocyte macrophage.