Pedunculagin의 Macrophage에 대한 항암활성 및 Nitric Oxide 생성

• 영문명: Augmentation of Macrophage Cytotoxicity and NO Production by Pedunculagin
• 발행기관: 대한약학회
• 저자명: 이도익(Do Ik Lee) 김형근(Hyung Keun Kim) 이민원(Min Won Lee) 최영욱(Young Wook Choi) 김하형(Ha Hyung Kim) 김은주(Eun Joo Kim)
• 간행물 정보: 『약학회지』제44권 제2호 (2000년), 175~181쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.04.29

영문 초록

Pedunculagin is an ellagitannin purified from Alnus hirsuta var. microphylla, Betulaceae. The effects of pedunculagin on the immune system have been characterized to induce enhancement of NK (natural killer) cell cytotoxicities against tumor cells. The present study investigated whether pedunculagin can enhance macrophage cytotoxicity against P815 tumor cells. Macrophage cultured with pedunculagin enhanced cytotoxicity in a dose dependent manner. In addition, the same treatments increased NO production, which plays important roles in the immune system. Taken together, these results demonstrate that pedunculagin significantly enhances cytolytic activities of macrophage.

키워드

Pedunculagin Macrophage NO production Antitumor activity.