단삼추출물의 Src-family Kinase 억제에 의한 항앨러지 효과

• 영문명: Salviae Radix Suppresses Mast Cell-mediated Allergic Response: Inhibition of Src-family Kinase
• 발행기관: 대한약학회
• 저자명: 김영미(Young Mi Kim)
• 간행물 정보: 『약학회지』제52권 제5호 (2008년), 370~375쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.10.31

영문 초록

In this study, the anti-allergic activity and mechanim of Salviae radix (SR) were investigated. The ethanol extract of SR showed significant inhibitory effect on degranulation from antigen-stimulated mast cells and it also inhibited the expression and secretion of TNF-α and IL-4 in antigen-stimulated RBL-2H3 cells. In the mast cell-mediated local animal allergy model, it suppressed the passive cutaneous anaphylaxis in a dose-dependent manner. As its mechanism of action, SR inhibited the activating phosphorylation of Syk, a downstream signaling molecule of Src-family kinase, for the activation of mast cells. The results of the study indicate that the anti-allergic activity of SR is mediated by the inhibition of Src-family kinase in mast cells.

키워드

Salviae radix anti-allergic activity mast cells Src-family kinase Syk kinase