β-Lactamase 억제작용이 기대되는 7-Arylidene Cephalosporanate 유도체의 합성

• 영문명: Synthesis of 7-Arylidene Cephalosporanates for β-Lactamase Inhibitor
• 발행기관: 대한약학회
• 저자명: 이종민(Jong Min Lee) 임철부(Chul Bu Yim) 임채욱(Chaeuk Im)
• 간행물 정보: 『약학회지』제52권 제4호 (2008년), 311~315쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.08.31

영문 초록

The synthesis of 7-arylidene cephalosporanates for β-lactamase inhibitor was described. The reactions of substituted benzyl halides [1]~[3] with triphenylphosphine gave triphenylphosphonium chlorides [4]~[6]. These phosphonium salts were treated with n-butyllithium to give ylides, which were reated with 7-oxocephalosporanate [7] by Wittig reaction to afford the 7-exomethylene cephalosporanates [8]~[10]. These cephalosporanates were oxidized to cephalosporanate sulfones [11]~[13] with mCPBA. The deprotection of benzhydryl cephalosporanate [8]~[13] with AlCl3 and NaHCO3 gave sodium salts of 7-arylidene cephalosporanates [14]~[19].

키워드

7-arylidene cephalosporanates β-lactamase inhibitors