Omega 3계열 불포화 지방산의 암세포주에 대한 성장 억제효과

• 영문명: Growth Inhibitory Effects of Omega-3 Unsaturated Fatty Acid against Cancer Cell Lines
• 발행기관: 대한약학회
• 저자명: 한두석(Du Seok Han) 최형규(Hyoung Gyu Choi) 강정일(Jeong Il Kang) 최화정(Hwa Jung Choi) 백승화(Seung Hwa Baek)
• 간행물 정보: 『약학회지』제52권 제4호 (2008년), 264~273쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.08.31

영문 초록

The inhibitory effect of omega-3 such as linolenic acid (LNA), docosahexaenoic acid (DNA) and eicosapentaenoic acid (EPA) on the growth of normal cell lines and cancer cell lines was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and 2,3-bis-2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-caboxanilide (XTT) methods. LNA was found to decrease the cell viability of human oral epithelioid carcinoma cells (KB) in the MTT assay, whereas EPA appeared to inhibit the cell adhesion activity of human skin melanoma cells (SK-MEL-3) in the XTT assay analysis. DPPH radical scavenging activity was examined on LNA, DHA and EPA at the concentration of 100 μM, where they showed about 53% scavenging activity. These results suggest that omega-3 unsaturated fatty acid has a potential anticancer activity.

키워드

unsaturated fatty acid cell viability cell adhesion activity cytotoxicity omega-3 DPPH radical scavenging activity