8-아미노우고닌 유도체의 Prostaglandin E2 생성에 대한 저해작용

• 영문명: Inhibitory Activity of 8-Aminowogonin Analogues Against Prostaglandin E2 Production
• 발행기관: 대한약학회
• 저자명: 장진희(Jinhee Jang) 신관석(Kwan-Seog Sin) 김현표(Hyun Pyo Kim) 박해일(Haeil Park)
• 간행물 정보: 『약학회지』제52권 제1호 (2008년), 85~91쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.02.28

영문 초록

8-Acyl and 8-sulfonylamidowogonin analogues were synthesized as potential anti-inflammatory agents. Nitration of 5,7-dihydroxyflavone (chrysin) followed by methylation of phenol groups and reduction of nitro group yielded 8-aminowogonin analogues. Acylation and sufonylation of 8-aminowogonin followed by demethylation reactions gave the title compunds. The synthesized wogonin analogues showed much reduced inhibitory activity on prostaglandin E2 (PGE2) production.

키워드

wogonin 8-acylamido 8-arylsulfonamido prostaglandin E2 (PGE2) production