Androstane과 Cholestane 유도체의 진통, 소염 및 항고지혈 효과

• 영문명: Antinociceptive, Antiinflammtory and Antihypercholesterolemic Effects of Androstane and Cholestane Derivatives
• 발행기관: 대한약학회
• 저자명: 김학순(Haksoon Kim) 마은숙(Eunsook Ma)
• 간행물 정보: 『약학회지』제51권 제6호 (2007년), 495~499쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.12.31

영문 초록

Seven epoxy- and hydroxyandrostane derivatives (DH-1~DH-7) and nine epoxy- and hydroxycholestane derivatives (CH-1~CH-9) with unsaturation in ring A and ring B were synthesized from DHEA and cholesterol, respectively. The antinociceptive effects of all synthesized compounds were measured by hot plate method. Most of androstane derivatives except 1α,2α-epoxy-4,6-androstadiene-3,17-dione (DH-3), and CH-6, CH-7 and CH-9 exhibited antinociceptive effect. 1,4-Androstadiene-3β,17β-diol (DH-5, 100 mg/kg, 35.8±7.39), 6α,7α-epoxy-1,4-androstadiene-3,17-dione (DH-4, 100 mg/kg, 32.6±5.50) and 5α,6α-epoxy-17-oxo-androstan-3β-ol (DH-1, 100 mg/kg, 32.5±2.98) were more effective than morphine (10 mg/kg, 30.6±0.5). The analgesic effects of androstane derivatives on acetic acid writhing in mice were lower than aspirin. The androstane derivatives were less effective than ibuprofen at inhibiting effects on the carrageenin induced paw oedema. 4,6-Cholestadien-3β-ol (CH-5), 1α,2α-epoxy-4,6-cholestadien-3β-ol (CH-7) and 7α-hydroxy- 4-cholesten-3-one (CH-9) showed the decrease of serum triglyceride and total cholesterol levels in poloxamer P-407 injected rat.

키워드

androstane cholestane antinociceptive antiinflammatory antihypercholesterolemic effect