마우스에서 L-Theanine의 기억력 회복능 및 Acetylcholinesterase 활성 억제

• 영문명: Improvement of Memory Impairment by L-Theanine Through Inhibition of Acetylcholinesterase Activity in Mice
• 발행기관: 대한약학회
• 저자명: 육동연(Dong Yeon Yuk) 김태일(Tae II Kim) 박상기(Sang Gi Park) 박형국(Hyoung Kook Park) 윤여경(Yeo Kyeung Yoon) 홍진태(Jin Tae Hong)
• 간행물 정보: 『약학회지』제51권 제6호 (2007년), 409~414쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.12.31

영문 초록

Acetylcholinesterase (AChE) plays a role in the progression of Alzheimer’s disease (AD). In this study, we examined the improving effect of L-theanine, a major amino acid in Japanese green tea (Camellia sinensis) on the scopolamine (1 mg/kg/mouse)-induced memory dysfunction in mice. Treatment with L-theanine (2, 4 mg/kg/mouse p.o.) in the drinking water for 7 days reversed the scopolamine-induced latency time and distance in the water maze test, latency time in the passive avoidance test, and inhibited AChE activity. This study suggests that L-theanine may be a useful agent for prevention of progression of AD.

키워드

theanine Alzheimer's disease memory acetylcholinesterase