자궁근종의 성선자국호르몬분버호르몬 효농제 치료에 있어 생리의 영향

• 영문명: The Effect of Menstration on GnRH Agonist Treatment for the Uterine Myoma
• 발행기관: 대한약학회
• 저자명: 한수경(Soo Kyung Han) 이명구(Myung Koo Lee) 한송이(Song Yi Han) 박미숙(Mi Sook Park) 임성실(Sung Cil Lim)
• 간행물 정보: 『약학회지』제51권 제6호 (2007년), 402~408쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.12.31

영문 초록

The aim of this study was to evaluate the effect of menstration among the influencing factors for the GnRH agonist (as G: depot goserelin 3.6 mg) therapy prior to the planned myomectomy for women who wanted to preserve their fertility. We reviewed total 48 patients. with the G therapy prior to the planned myomectomy from August 1st, 2005 to August 31st, 2006. The patients were classified by the G group (n=28) and the immediate surgery (as S) group (n=20). The G group (n=19) underwent the G therapy for 3 month courses, and then the efficacy was evaluated by menstruation and the myoma volumes. In the G group (n=19), therapy was effective, and the mean age was 32.4±6.5 years. After the completion of G thera py, the mean volume of the myoma by ultrasonography was reduced to 85.2±71.2 cm3 comparing of 430.6±248.8 cm3 at first visit. The 11 patients had menstruation and the rest 8 patients with amenorrhea had less reduced volume of the myoma (124.05±79.85 cm3 v.s. 329.41±234.0 cm3 p<0.05). In the immediate S group, the myoma volumes by sonography was also checked for accuracy (α=1.0). As the result, the initial myoma volume had the positive correlations to the effectiveness with G therapy. However, the occurrence and frequency of the menstruation during the G therapy had a negative correlation. In conclusion, the use of G prior to the planned myomectomy was effective in reducing myoma volume and the menstruation.

키워드

goserelin GnRH agonist myomectomy