패혈성 쇼크에서 간의 유황함유 아미노산 대사

• 영문명: Hepatic Metabolism of Sulfur Amino Acids During Septic Shock
• 발행기관: 대한약학회
• 저자명: 강건욱(Keon Wook Kang) 김상겸(Sang Kyum Kim)
• 간행물 정보: 『약학회지』제51권 제6호 (2007년), 383~388쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.12.31

영문 초록

It has been reported that sulfur-containing intermediates or products in the transsulfuration pathway including S-adenosylmethionine, 5'-methylthioadenosine, glutathione and taurine can prevent liver injury mediated by inflammation response induced by lipopolysaccharide (LPS) treatment. The present study examines the modulation of hepatic metabolism of sulfur amino acid in a model of acute sepsis induced by LPS treatment (5 mg/kg, iv). Serum TNF-alpha and hepatotoxic parameters were significantly increased in rats treated with LPS, indicating that LPS results in sepsis at the doses used in this study. LPS also induced oxidative stress determined by increases in malondialdehyde levels and decreases in total oxyradical scavenging capacities. Hepatic methionine and glutathione concentrations were decreased, but S-adenosylhomocysteine, cystathionine, cysteine, hypotaurine and taurine concentrations were increased. Hepatic protein expression of methionine adenosyltransferase, cystathionine beta-synthase and cysteine dioxygenase were induced, but gamma-glutamylcysteine ligase catalytic subunit levels were decreased. The results show that sepsis activates transsulfuration pathway from methionine to cysteine, suggesting an increased requirement for methionine during sepsis.

키워드

sepsis lipopolysaccharide sulfur amino acid hepatic metabolism transsulfuration