목향(木香)으로부터 분리된 Sesquiterpene 화합물의 암세포 생육저해에 대한 활성

• 영문명: Sesquiterpene Lactones from Saussurea lappa and Their Cell Proliferation Effects on Human Breast Cell Lines
• 발행기관: 대한약학회
• 저자명: 박현선(Hyun Sun Park) 최은정(Eun Jeong Choi) 이용수(Yong Soo Lee) 김건희(Gun Hee Kim)
• 간행물 정보: 『약학회지』제51권 제2호 (2007년), 145~149쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.04.30

영문 초록

Saussurea Radix, the dried roots of Saussurea lappa Clark (Compositae), has been used in oriental traditional medicine for aromatic stomachic. Present study was carried out for the anticancer effect of Saussurea Radix. Bioassay-directed fractionation of Saussurea Radix led to the isolation of two sesquiterpenes, dehydrocostuslactone (1) and costunolide (2). The structures of 1 and 2 were elucidated by spectral methods (MS, IR, 1H and 13C NMR). These compounds showed a potent cell proliferation activity against human breast cancer cell MCF-7 and MDA-MB-453.

키워드

Saussurea lappa Compositae sesquiterpene lactone guaianolide germacrane cell proliferation activity