호장으로부터 분리한 안트라퀴논 및 스틸벤 화합물의 지질과산화 저해활성

• 영문명: Antilipoperoxidant Activity of Anthraquinone and Stilbene from Polygunum cuspidatum
• 발행기관: 대한약학회
• 저자명: 주시몽(Si Mong Joo) 이민원(Min Won Lee) 양기숙(Ki Sook Yang)
• 간행물 정보: 『약학회지』제51권 제2호 (2007년), 140~144쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.04.30

영문 초록

Polygunum cuspidatum has veen used as treatments of dermatitis, gonorrhea, inflammation, and hyperlipidaemia in traditional medicine. We examined liver protective effect on CCl4 inducing hepatotoxicity, and anti-oxidative activity by TBA method. Phytochemical examination of Polygunum cuspidatum led to the isolation and characterization of emodin 8-O-β-D-glucopyranoside (compound 1), and trans-resveratrol 3-O-β-D-glucopyranoside (compound 2). Compounds 1 and 2 enhanced the inhibition of anti-lipid peroxidative effects in liver homogenate. In chemical parameters obtained from serum analysis, compounds 1 and 2 also revealed significant decrease in hepatotoxicity. These results suggested that the analysis, compounds 1 and 2 also revealed significant decrease in hepatotoxicity. These results suggested that the anthraquinone and stilbene which were isolated from Polygunum cuspidatum might be used as therapeutic agent of hepatitis.

키워드

Polygonum cuspidatum emodin 8-O-β-D-glucopyranoside trans-resveratrol 3-O-β-D-glucopyranoside hepatotoxicity