크로몬 유도체의 물성 및 활성검색

• 영문명: Properties and Activity Screening of Chromone Derivatives
• 발행기관: 대한약학회
• 저자명: 김영로(Young Ro Kim) 이상현(Sang Heyn Lee) 김경순(Kyoung Soon Kim) 정춘식(Chun Sik Cheong) 정재훈(Jae Hoon Cheong) 김박광(Bak Kwang Kim)
• 간행물 정보: 『약학회지』제44권 제2호 (2000년), 107~114쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.04.29

영문 초록

We have synthesized 4-isonitroso-4H-1-benzopyran and 4-amino-2,3-dihydro-4H-1-benzopyran of chromone derivatives by using condensation method. Physico-chemical properties of these compounds were measured and analyzed by UV and HPLC method. The correaltion coefficient of their methanol solutions by UV were 0.9992 and 0.9994, respectively. And oxime compound was resolved within 4 min and had a detection limit of 3ng at S/N=3 by HPLC under the same conditions. Anti-diabetic effect of chromone derivatives were investigated in the streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in male Sprague-Dawley rats by injections of STZ (45mg/kg, I.v.). The investigation of the hair growth effect of isonitrosobenzopyran and 4-aminobenzopyran on the hair of black mouse (C57BL/6) was also carried out. The administration of their ethanol solution to the black mouse (C57BL/6) through skin them promoted the growth of hair.

키워드

4-Isonitroso-4H-1-benzopyran 4-amino-2,3-dihydro-4H-1-benzopyran synthesis blood glucose level black mouse(C57BL/6) hair growth effect.