신성 고혈압 흰쥐의 초기단계에서 내피 의존적인 혈관반응의 변화

• 영문명: The Alteration of Endothelium-Dependent Vascular Response at Early Stage of 1K1C Renal Hypertensive Rats
• 발행기관: 대한약학회
• 저자명: 김주원(Ju Won Kim) 김학림(Hak Lim Kim) 박조영(Jo Young Park) 염지현(Ji Hyoun Youm) 라현오(Hyen O La) 이영욱(Young Wook Lee) 안형수(Hyung Soo Ahn) 손의동(Uy Dong Sohn) 허인회(In Hoi Huh)
• 간행물 정보: 『약학회지』제43권 제6호 (1999년), 843~850쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.12.28

영문 초록

We investigated whether endothelium-derived NO and endothelin-1 might result in the enhanced vasoconstriction induced by administration of norepinephrine (NE) at the early stage of one-kidney, one-clip (1K1C) renal hypertensive rats. We also studied the relationship of renin-angiotensin system (RAS) using rat aorta in this hypothesis. L-NMMA (30mcM) and L-NAME (30mcM) enhanced vasoconstriction induced by NE in thoracic aorta of control rats. However angiotensin converting enzyme (ACE) inhibitor didn't. The aorta of 1K1C rats showed a significantly exaggerated contractile response to NE as compared with control rats. Rubbing the endothelium abolished this difference. Ach and SNP-induced vasorelaxation show no significant difference between 1K1C and control rats. The treatment of phosphoramidon (10mcM) and oral administration of captopril (0.05, w/v%) abolished the exaggerated contractile response to NE at early stage of 1K1C rats. These results suggest that the increase of contractile response at the early phase in 1K1C rat is partially involved in the activation of ACE.

키워드

L-NMMA L-NAME phosphoramidon captopril hypertention.