별불가사리의 항돌연변이 활성

• 영문명: Antimutagenic Activity of Asterina pectinifera
• 발행기관: 대한약학회
• 저자명: 함정혜(Jung Hye Ham) 한영환(Yeong Hwan Han) 박창훈(Chang Hun Park) 이동웅(Dong Ung Lee)
• 간행물 정보: 『약학회지』제43권 제6호 (1999년), 771~775쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.12.28

영문 초록

The antimutagenic activities of the total extract and several fractions of starfish, Asterina pectinifera (Asteriidae), were investigated in vitro by SOS chromotest with Escherichia coli PQ37 and Ames test with Salmonella typhimurium TA100. When various fractions was tested, the chloroform and butanol fractions showed low induction factors, which means both fractions increased antigenotoxicity against the base substitution mutagen MNNG. Even though higher antigenotoxic effect of the chloroform fraction, no effective result of Ames test was found in revertant formation of S. typhimurium TA100. The most effective antigenotoxic and antimutagenic fraction was a butanol one: I.e., When 0.5mg/tube of butanol fraction was applied, the induction factor was 0.68. As the concentration of the fraction was increased, an induction factor was significantly reduced to 0.47. The 2.5mg/tube of the fraction potently inhibited the formation of revertants of S. typhimurium TAIOO by about 81%. There was no cytotoxic effect of butanol fraction against S. typhimurium TA100. This result might be useful for further study to search a possible anticancer agent from the starfish, Asterina pectinifera.

키워드

Asterina pectinifera antimutagenic activity SOS chromotest ames test.