5,6-디플루오르-2-아미노인단.염산염의 합성

• 영문명: Synthesis of 5,6-difluoro-2-aminoindan.HCl
• 발행기관: 대한약학회
• 저자명: 마은숙(Eun Sook Ma)
• 간행물 정보: 『약학회지』제43권 제6호 (1999년), 751~755쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.12.28

영문 초록

3,4-Difluoroamphetamine.HCl and 5,6-difluoro-2-aminoindan.HCl were synthesized as serotonergic agents. 3,4-Difluorobenzaldehyde was condensed with nitroethane and reduced with LiAlH4 to obtain 3,4-difluoroamphetamine. And 5,6-difluro-2-aminoindan.HCl was synthesized through reactions of condensation with malonic acid, 10% Pd-C reduction, cyclization with polyphosphroic acid, oximation and catalytic hydrogenation.

키워드

3,4-Difluoroamphetamine 5,6-Difluoro-2-aminoindan Serotonergic agents.