ATP-의존성 K+ Channel 차단제인 Gilbenclamide의 중추적 이뇨작용에 대한 신장 신경제거와 Cromakalim의 영향

• 영문명: Effects of Renal Denervaton and Cromakalim on Central Diuretic Action of Gilvenclamide, an ATP-dependent K+ Channel Blocker, in Dogs
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 임광남(Kwang Nam Ko) 정경희(Kuong Hee Chung)
• 간행물 정보: 『약학회지』제43권 제5호 (1999년), 674~681쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.10.28

영문 초록

This study was performed to investigate the effect of renal denervation and cromakalim, a K+ channel opener, on central diuretic action of glibenclamide, an ATP-dependent K+ channel blocker, in dog. Diuretic action of glibenclamide administered into the vein was weakened markedly by renal denervation and pretreatment of cromakalim. Above results suggest that central diuretic action of glibenclamide is mediated by renal nerves and K+ channel localized in kidney.

키워드

Glibenclamide central diuretic action renal denervation cromakalim dog.