천연감미료 스테비오사이드와 스테비올의 생체내, 시험관내 유전독성평가

• 영문명: In vitro and In vivo Evaluation of Genotoxicity of Stevioside and Steviol, Natural Sweetner
• 발행기관: 대한약학회
• 저자명: 오혜영(Hye Young Oh) 한의식(Eui Sik Han) 최돈웅(Don Woong Choi) 김종원(Jong Won Kim) 손수정(Soo Jung Son) 엄미옥(Mi Ok Eom) 강일현(Il Hyun Kang) 강혁준(Hyuck Joon Kang) 하광원(Kwang Won Ha)
• 간행물 정보: 『약학회지』제43권 제5호 (1999년), 614~622쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.10.28

영문 초록

The standard operation procedure of mouse lymphoma L5178Y tk+/- -3.7.2C gene mutation assay (MOLY) has been regarded as a sensitive In vitro mammalian cell gene mutation assay that is capable of detecting clastogens as well as mutagens. Using MOLY, one of natural sweetner, stevioside (5mg/ml) and its aglycon, steviol (340mcg/ml) were evaluated the mutagenicity. Stevioside and steviol did not induce mutagenicity in MOLY. On the other hand, stevioside (250mg/kg, B.W.) and steviol (200mg/kg, B.W.) were also evaluated their ability to induce mucronuclei in regenerating hepatocytes and bone marrow cells of ddY mice. From these results, stevioside and steviol did not induce any mutagenic effect both MOLY and In vivo micronucleus test.

키워드

Mouse lymphoma assay(MOLY) micronudeus(MN) stevioside, steviol.