흰쥐 조직에서 카드뮴 결합 고분자량 단백질 [Cd-BP(II)]의 유도

• 영문명: Induction of Cd-binding High Molecular Weight Protein [Cd-BP(II)] in Rat Tissues
• 발행기관: 대한약학회
• 저자명: 천기정(Ki Jung Chun) 김봉희(Bong Hee Kim)
• 간행물 정보: 『약학회지』제43권 제5호 (1999년), 591~597쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.10.28

영문 초록

The study was carried out on the biochemical chracters of Cd-BP(II) after isolation and purification of the protein from the liver of rat ip injection with Cd. A continued study has been doing whether Cd-BP(II) could be induced by Cd or by the other metals such as Zn and Cu. Antisera were made against the antigen of Cd-BP(II) from New Zealand white rabbits. We carried out g-globulin purification, then Ouchterlony test and gel immunodiffusion test. Cd-BP(II) was also found in normal tissues of rat. It was induced up to a considerable level by Cd, whose induced level was higher than that Cu or Zn treatment. The level of induction by Cu or Zn pretreatment plus Cd treatment was lower than that by single treatment of Cu or Zn. Such a result was presumably related to the Cd toxicity.

키워드

Cd-binding high molecular weight protein Ouchterlony test gel immunodiffusion test Cd administration.