Corrosolin 및 Compound-2 : Annona cherimolia 씨앗으로부터 분리된 세포독성 Annonaceous acetogenin

• 영문명: Corrosolin and Compoumnd-2 : Cytotoxic Annonaceous Acetogenins from the Seeds of Annona cherimolia
• 발행기관: 대한약학회
• 저자명: 김달환(Dal Hwan Kim) 우미희(Mi Hee Woo)
• 간행물 정보: 『약학회지』제43권 제5호 (1999년), 584~590쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.10.28

영문 초록

Bioactivity-directed fractionation from the seeds of Annona cherimolia resulted in the isolation of two known cytotoxic compounds : corrosolin (1) and compound-2 (2). The structures of these compounds were characterized on the basis of chemical and spectral data. Corrosolin has a relative stereochemical relationship of threo/trans/threo for the mono-tetrahydrofuran (THF) ring with two flacking hydroxyls, from C-15 to C-20, which is the annonacin type. Compound-2 has a relative stereochemical relationship of threo/trans/threo/trans/threo for the adjacent bis-THF ring with two flanking hydroxyls, such as in the asimicin type. The absolute configurations of carbinol carbons in corrosolin were determined as 10R, 15R, and 20R by analysis of its Mosher ester derivatives. Corrosolin and compound-2 are known, but are first isolated in this plant.

키워드

Annonaceous acetogenin Annona cherimolia corrosolin compound-2 cytotoxicity.