1,3-Dioxolan-2-yliden 유도체들의 합성과 항진균 활성

• 영문명: Synthesis of 1,3-Dioxolan-2-yliden Derivatives and Their Antifungal Activities
• 발행기관: 대한약학회
• 저자명: 김영섭(Y. S. Kim) 김우정(W. J. Kim) 김범태(B. T. Kim) 박노균(N. K. Park) 박창식(C. S. Pak)
• 간행물 정보: 『약학회지』제43권 제5호 (1999년), 566~571쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.10.28

영문 초록

(1H-1,2,4-Triazolyl) methyl-4-(sub.) phenyl-5-methyl-1,3-dioxolan-2-yliden (3) derivatives were synthesized and tested for their antifungal activities. The designed compounds with a 1,2,4-triazolyl-methyl group at the 4-position of 1,3-dioxolan-2-yliden moiety were synthesized by reaction of difluorinated olefins (2) with (2R,3R)-2-(2,4-dihalophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol (1). These compounds were tested for in vitro antifungal activities against 16 fungi species. The MIC values were determined by the micro broth dilution method. In general, 1,3-dioxolan-2-[1-(3,4-methylenedioxyphenyl) methylidene)-1,3-dioxolon-4-yl(1H-1,2,4-triazol1yl)methane showed superior antifungal activities to fluconazol and ketoconazol.

키워드

Antifungal activity 1,3-dioxolane-2-yliden vinyl fluoride.