새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성

• 영문명: Synthesis and Antitumor Activity of Novel Gericudranin E Derivatives
• 발행기관: 대한약학회
• 저자명: 박재호(Jae Ho Park) 박경란(Kyoung Lan Park) 호현순(Hyun Soon Ho) 김희두(Hee Doo Kim) 표명윤(Myoung Yun Pyo)
• 간행물 정보: 『약학회지』제43권 제5호 (1999년), 559~565쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.10.28

영문 초록

The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their anti-tumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.

키워드

Gericudranin E synthesis antitumor MTT assay.