홍화씨의 경골골절치유에 미치는 영향

• 영문명: Effects of Safflower-seed on the Fracture Healing in Rat Tibia
• 발행기관: 대한약학회
• 저자명: 정수연(Soo Youn Chung) 최현진(Hyun Jin Choi) 정면우(Myeon Woo Chung) 안미령(Mee Ryung Ahn) 유태무(Tae Moo Yoo) 류항묵(Hang Mook Rheu) 양지선(Ji Sun Yang)
• 간행물 정보: 『약학회지』제43권 제4호 (1999년), 526~534쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.08.28

영문 초록

We investigated the effect of safflower-seed on fracture healing of fracture model in rat. Fracture healing was evaluated by examining the degree of wound healing macroscopically, radiography, bone histomorphometry and biochemical examination. After 1,3,5,7 days, the wound healing was accelerate in safflower-seed diet group. Radiography does not reveal the difference in fracture healing between two groups. After 2 weeks, safflower-seed had a significant, stimulatory effect on external callus formation(p<0.05). But after 4,6,8 weeks, no difference was observed between normal and safflower-seed diet group in callus size. Urinary hydroxyproline, osteocalcin and total alkaline phosphatase decreased significantly (p<0.05) in safflower-seed treated group at 2 week after fracture.

키워드

Fracture safflower callus volume urinary hydroxyproline osteocalcin total alkaline phosphatase.