송악의 페놀성 물질의 간 보호효과

• 영문명: Protective Effects of the Phenolic Compounds from the Leaves of Hedera rhombea on Hepatic Injury
• 발행기관: 대한약학회
• 저자명: 김경숙(Kyoung Sook Kim) 송지영(Jie Young Song) 이인란(Ihn Rhan Lee)
• 간행물 정보: 『약학회지』제43권 제4호 (1999년), 516~525쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.08.28

영문 초록

Hedera rhombea (HR) has been used for treatments of hemorrage, chronic catarrh, jaundice, lithisis and convulsion. This study was done to isolate active compounds that have protective effect on liver damage. BuOH and EtOAc fractions of HR recovered serum glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT) and gamma-glutamyltranspeptidase (gamma-GTP) activities in CCl4 treated rats. We isolated 7 phenolic compounds from BuOH and EtOAc fractions, which were identified as 3-caffeoyl quinic acid, 3,4-di-O-caffeoyl quinic acid, 3,4-di-O-caffeoly quinic acid, 4, 5-di-O-caffeoyl quinic acid by chemical and spectral analysis. These compounds reduced significantly serum GOT and GPT elevated by CCl4 treatment in rats, and 3-caffeoyl quinic acid, 3,5-di-O-caffeoyl quinic acid and caffeic acid also showed mild inhibitory activity against human immunodeficiency virus.

키워드

Hedera rhombea Araliaceae 3-caffeoyl quinic acid,3 4-di-O-caffeoyl quinic acid,3 5-di-O-caffeoyl quinic acid,4 5-di-O-caffeoyl quinic acid caffeic acid methyl3 4-di-O-caffeoyl quinic acid methyl3 5-di-O-caffeoyl quinic acid S-GOT S-GPT antiviral activity.