Monocrotaline에 의해 유발된 폐고혈압 흰쥐에 있어 Enalapril 및 Ginkgo biloba Extract (EGb 761)의 병용 투여시 억제효과

• 영문명: Inhibitory Effect of Enalapril in Combination with Ginkgo biloba. Extract (EGb 761) on the Monocrotaline-induced Pulmonary Hypertension Rats
• 발행기관: 대한약학회
• 저자명: 이영미(Young Mi Lee) 안형수(Hyung Soo Ann) 임세진(Se Jin Lim) 안령미(Ryoung Me Ahn)
• 간행물 정보: 『약학회지』제43권 제4호 (1999년), 487~493쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.08.28

영문 초록

Effects of Ginkgo biloba extract(EGb 761) on the anti-pulmonary hypertensive action of enalapril were evaluated in rats. Pulmonary hypertension was induced by monocrotaline treatment (60mg/kg, I.p.) in normotensive rats. In the systolic pulmonary artery pressure, the control group was 33 +/- 2mmHg, comparing to the normal group of 19 +/- 1 mmHg. That of enalapril group(20mg/kg/day, p.o.) was 26 +/- 2 mmHg, and that of combined group of enalapril and Ginkgo biloba extract (EGb 761;60mg/kg/day, p.o.) was 20 +/- 2 mmHg. In the isolated lung preparation, acetylcholine, which was endothelium dependent vasodilator, induced the decrease of pulmonary artery perfusion pressure(-2.0 +/- 0.7mmHg) in normal group, but the increase of that of 3.4 +/- 0.6 and 3.0 +/- 0.9mmHg in control and enalapril group, respectively. And that of the combined group was -0.5 +/- 0.2mmHg. In the isolated pulmonary artery, acetylcholine(10-5M) induced the relaxation of 65 +/- 6% in normal group, but 15 and 8% in control and enalapril group, respectively. And that of the combined group was resulted 55 +/- 2%. These results suggested that co-administration of Ginkgo biloba extract(EGb 761) potentiated the anti-pulmonary hypertensive effects of enalapril through the increase of pulmonary vasodilation due to the protection of endothelial cell by antioxidant action of Ginkgo biloba extract (EGb 761).

키워드

Pulmonary hypertension monocrotaline Ginkgo biloba extract(EGb 761) enalapril systolic pulmonary artery pressure pulmonary artery perfusion pressure.